In this episode, Dr. Rena Malik, MD hosts Dr. Layne Norton to dissect the intricacies of metabolism, weight loss, and the influential role of resistance training. They delve into the inaccuracies of online calorie calculators, the impact of metabolic adaptations from long-term dieting, and the critical relationship between calories in and calories out. Dr. Layne highlights the significant yet often misunderstood effects of hormones on metabolic rate and advocates for the necessity of sustainable lifestyle and behavior changes for long-term weight loss. The discussion also underscores the benefits of strength training for longevity, particularly for the elderly, while providing valuable insights into managing stress and promoting overall well-being. Listeners will gain practical tips on effective weight management, debunking common nutrition myths, and fostering a healthier lifestyle.