In this episode, Layne sits down with renowned researcher and ketogenic diet expert Dr. Dominic D’Agostino to dive deep into the science of the ketogenic diet. Professor Dominic D’Agostino (University of South Florida Morsani College of Medicine / Institute for Human and Machine Cognition) is one of the leading voices on nutritional ketosis, exogenous ketones, and metabolic therapies. Together, they unpack what the research actually shows about keto – beyond the hype and social media claims.
They cover the mechanisms of ketosis, potential therapeutic applications (including epilepsy, metabolic health, neurological conditions, and ongoing research areas like cancer support), practical considerations for implementing a well-designed ketogenic approach, common misconceptions, protein and micronutrient needs, exogenous ketones, and how keto stacks up for fat loss, performance, and long-term adherence compared to other dietary strategies. Expect an evidence-based, no-BS conversation that prioritizes data over dogma.
Citations
Ketones, Epilepsy, and Neuroprotection
- Ketogenic diets for drug-resistant epilepsy
- Ketone esters and hyperbaric oxygen-induced seizures
- Follow-up oxygen-toxicity work
- β-hydroxybutyrate and the NLRP3 inflammasome
Alzheimer’s Disease, MCI, and Cardiac Effects
- Ketogenic interventions and cognition in Alzheimer’s/MCI
- MCTs and cognition in MCI/Alzheimer’s
- Six-month ketogenic MCT RCT in MCI
- β-hydroxybutyrate, cardiac output, and vascular resistance
- Oral ketone esters in heart failure
Ketogenic Diets, Cancer, and Cachexia
- Overall human evidence for ketogenic diets in cancer
- Earlier systematic review of adult cancer studies
- Muscle mass and cancer survival
Ketogenic Diets, Hypertrophy, Appetite, and Fasting
- Ketogenic diets and resistance-training hypertrophy
- Ketogenic diets and appetite suppression
- Time-restricted feeding with resistance training
- Broader review of intermittent fasting plus resistance training
Resistance-Training Discussion
- Weekly sets and hypertrophy
- Drop sets and hypertrophy
- Proximity to failure, hypertrophy, and strength
- Reduced training volume for maintenance
Metabolic Advantage and Cardiovascular Risk
